Cancer Weekly

Breast Cancer - Fuzzy c-means clustering-based method used to segment breast lesions from MRI

Cancer Diagnostics - CD10 expression used to differentiate trichoepithelioma from basal cell cancer

Lung Cancer - A GSTP1 polymorphism may be linked to survival in advanced non-small cell lung carcinoma

Lymphoma - Phosphatidylinositol-3 kinase/Akt inhibition promoted apoptosis in Hodgkin lymphoma

Prostate Cancer - Expandable endorectal coils used to improve alignment of prostate MR images

Adrenocortical Cancer - Therapeutic strategies for treating adrenocortical carcinoma discussed

Apoptosis - Cathepsin B and its interacting proteins implicated in apoptosis of ovarian cancer cells

Apoptosis - Reports add new data to apoptosis research

Apoptosis - Two tumor-suppressor genes regulate cell proliferation and apoptosis

Astrocytomas - Definition and diagnostic implications of gemistocytic astrocytomas reviewed

Astrocytomas - Functional outcome after low-grade astrocytoma treatment in childhood described

Bladder Cancer - Bladder cancer inhibited by 1,1-bis(3'-indolyl)-1-(P-substitutedphenyl)methanes

Bladder Cancer - Expression of E-cadherin and alpha-, beta-, gamma-catenins in bladder cancer analyzed

Bladder Cancer - Histone deacetylase inhibitors modulate sensitivity of TRAIL-resistant bladder tumor cells

Bladder Cancer - Lymph node metastasis in bladder cancer described

Bladder Cancer - Morphology and DNA degeneration during autoschizic cell death in bladder cancer described

Bladder Cancer - Surrogacy of tumor downstaging for evaluating invasive bladder cancer assessed

Bladder Cancer - p53 protein transduction therapy targets and inhibits bladder cancer cell growth

Bone Marrow - Clinical use of CXCR4 antagonists to prevent neuroblastoma metastasis is not supported

Bone Marrow Transplantation - Allogeneic BMT and patient eligibility based on psychosocial criteria

Bone Marrow Transplantation - Use of alternative donor transplants in children with early Ph+ ALL encouraged

Brain Cancer - Head circumference at birth linked to risk of brain cancer in childhood

Brain Cancer - Phenotypic changes in glioma endothelial cells demand culture constraints

Brain Cancer - Research uncovers pathway to overcome brain tumor resistance to cell death

Brainstem Metastases - Brainstem metastases might be managed using gamma knife radiosurgery

Breast Cancer - A new I kappa B kinase beta inhibitor prevents human breast cancer progression

Breast Cancer - ACIS assessment of HER-2/neu expression fast, accurate, and cost-effective

Breast Cancer - Alliance publishes international breast health guidelines for developing countries

Breast Cancer - Anandamide inhibited adhesion and migration of breast cancer cells

Breast Cancer - Breast cancer survivors making surgery decisions with limited information

Breast Cancer - E2F-HDAC complexes negatively regulate breast cancer tumor suppressor gene

Breast Cancer - First disease-specific protein library opens new path for drugs to fight breast cancer

Breast Cancer - Hereditary breast and ovarian cancers reviewed

Breast Cancer - High levels of angiogenic protein are linked to the presence of macrophages in breast tumors

Breast Cancer - Idarubicin displayed cytotoxic effect on breast cancer multicellular spheroids

Breast Cancer - Orathecin exhibited minimal clinical benefit in metastatic breast cancer

Breast Cancer - Outreach to address noncompliance issues may enhance mammography screening rates

Breast Cancer - Pregnancy hormones and maternal diet may reduce breast cancer risk in offspring

Breast Cancer - Reports advance knowledge in breast cancer research

Breast Cancer - Researchers describe findings in breast cancer studies

Breast Cancer - Researchers develop guidelines for treatment of breast cancer during pregnancy

Breast Cancer - Researchers publish new studies and findings in the area of breast cancer

Breast Cancer - Stat3 signaling induces survivin gene expression and apoptosis resistance in breast cancer cells

Breast Cancer - Studies add new findings to breast cancer body of knowledge

Breast Cancer - Studies advance knowledge in breast cancer research

Breast Cancer - Study examines racial disparities among breast cancer patients

Breast Cancer - The VEGF receptor inhibitor AZD2171 diminished breast tumor size in cancer models

Breast Cancer - Three new human BRCA1 mutant cell lines could aid in understanding the function of BRCA1

Breast Cancer - Women with non hereditary breast cancer more likely to develop breast cancer again

Burkitt Lymphoma - Expression of BIC and miR-155 is not a common finding in Burkitt lymphoma

Business & Finance - Cancer-focused pharmaceutical company signs agreement for $25.5 million sale of stock

Business & Finance - Cytoskeleton-focused company reports Q4 net loss of $11.1 million

Business & Finance - German software founder invests EUR 22 million in Tuebingen cancer-focused biotech company

Business Update - Cancer screening systems developer changing its name to CytoCore

Business Update - Cancer-focused firm receives large-scale contract for cancer afterloaders in Venezuela

Cancer Diagnostics - Clinical value of complexed PSA and total PSA in cancer diagnostics assessed

Cancer Diagnostics - Colon dissection approach deemed advantageous for evaluating CT colonography

Cancer Diagnostics - Fine-needle aspirates of hepatocellular cancer could be misclassified as adenocarcinoma

Cancer Diagnostics - Positron emission tomography used to detect bone marrow involvement in lymphoma

Cancer Diagnostics - Residual tumor after radiofrequency ablation of liver metastasis detected with dual-modality PET/CT

Cancer Gene Therapy - Analogue 4 is a strong candidate for gene therapy of lung tumors

Cancer Gene Therapy - Antisense-cisplatin combination treatment is potentially useful in breast cancer

Cancer Gene Therapy - Co-transfection into lung cancer cells line can increase chemosensitivity

Cancer Gene Therapy - Combination gene therapy increases anti-tumor effect in a CT26 tumor model

Cancer Gene Therapy - Combination therapy produces adenovirus transduction and enhanced therapeutic efficacy

Cancer Gene Therapy - DNA methyltransferase inhibition prevents prostate cancer tumorigenesis

Cancer Gene Therapy - Pancreatic carcinoma can be treated by adenoviral mediated gene transfer of vasostatin

Cancer Gene Therapy - TRAIL recombinant adenovirus displays antitumor activity in human malignant glioma cells

Cancer Incidence - Incidence of cancer around Amsterdam Airport Schiphol analyzed

Cancer Mortality - Incidence of cancer mortality due to repetitive CT scanning estimated

Cancer Research - DNA structure gives insight into treatment against cancer

Cancer Research - InPath System developer inks research agreement with University Hospitals of Cleveland

Cancer Research - Missouri teaching hospital selects systems to improve cancer treatment planning and tumor targeting

Cancer Research - Oddly shaped DNA found to create instability associated with leukemia

Cancer Research - Perchloroethylene exposure affects various pathways involved in cancer induction

Cancer Research - Pharma company completes Coramsine phase I trial, commences phase II trial

Cancer Research - U.S. FDA requests additional data to establish bioequivalence between LEP-ETU and Taxol

Cancer Risk Factors - Recent findings illuminate research in cancer risk factors

Cancer Therapy - A biologic work up of adult T-ALL cases is recommended to design tailored therapies

Cancer Therapy - Abbott has selected two additional cancer targets for development, genomics firm reports

Cancer Therapy - Allogeneic hematopoietic cell transplantation is a therapy for hematologic malignancies

Cancer Therapy - Antitumor benzothiazoles showed inhibitory activity against cancer cell lines

Cancer Therapy - Authorities okay launch of phase Ib/II human clinical trial for anticancer drug CTCE-9908

Cancer Therapy - Breast cancer angiogenesis declined in response to resveratrol

Cancer Therapy - COX-2 inhibition augments the efficacy of a cancer vaccine

Cancer Therapy - Cancer cell ablation occurs using irreversible electroporation

Cancer Therapy - Cancer dose-response characteristics of 2,3,7,8-tetrachlorodibenzodioxin studied

Cancer Therapy - CoFactor phase IIb trial surpasses 50% enrollment milestone

Cancer Therapy - Combination sorafenib and gemcitabine stabilizes disease in advanced solid tumors

Cancer Therapy - Endostatin fusion protein focuses on neovascular endothelial cells to control tumor growth

Cancer Therapy - Evidence of sex-based differences in lung cancer grows

Cancer Therapy - Gefitinib was well tolerated in a phase II study of patients with renal-cell carcinoma

Cancer Therapy - Higher serum hemoglobin levels may predict enhanced response to neoadjuvant chemotherapy

Cancer Therapy - IV Hycamtin receives European marketing approval for relapsed small cell lung cancer

Cancer Therapy - Irofulven cytotoxicity characterized in human cancer cells

Cancer Therapy - Oleanolic derivative compound protects against liver cancer

Cancer Therapy - Recent findings in cancer therapy provide new insights

Cancer Therapy - Reports add new data to cancer therapy research

Cancer Therapy - Reports describe recent advances in cancer therapy research

Cancer Therapy - Researchers describe findings in cancer therapy studies

Cancer Therapy - Sirolimus reduces risk of cancer in kidney transplant patients, published study shows

Cancer Therapy - Standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome presented

Cancer Therapy - Studies add new findings to cancer therapy body of knowledge

Cancer Therapy - Tiron identified as bortezomib blocker

Cancer Therapy - Topoisomerase II inhibitors enhanced by using polypeptide inhibitor of c-Myc

Cancer Therapy - Vascular endothelial growth factor-blocking antibodies thwart tumor growth in animal models

Cancer Vaccine - Anti-tumor DNA vaccines protect against tumor development

Cancer Vaccine - Antitumor efficacy of CD137 ligation is maximized by tumor vaccine

Cancer Vaccine - Chimeric DNA vaccine reverses morphine-induced immunosuppression and tumorigenesis

Cancer Vaccine - Commercial launch of telomerase-immortalized cell line through ATCC announced

Cancer Vaccine - H-2D^b-specific CD8+ T-cell epitopes inhibit tumor growth

Cancer Vaccine - IL-2/liposome potentiates immune responses to cancer vaccine

Cancer Vaccine - Therapeutic cancer vaccines amplify tumor-specific regulatory T cells

Cancer Vaccine - Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses

Cancer Vaccines - Recent studies add new data to cancer vaccines research

Carcinogenesis - Deregulation in human rectal carcinomas depends on aneuploidy

Cell Biology - Mechanism potentially explains evolution of cell signaling pathways

Cerebral Metastases - LINAC Radiosurgery used to treat cerebral metastases

Cervical Cancer - Confocal microscopy could aid detection of cervical precancerous lesions

Cervical Cancer - Ethnic factors may influence cervical cancer screening rates in Vietnamese women

Cervical Cancer - Gardasil, a cervical cancer vaccine, to receive priority review from the U.S. FDA

Cervical Cancer - HPV DNA testing is effective to triage women with minor cervical lesions

Cervical Cancer - Potential role of oxidative stress in the evolution of cervical cancer evaluated

Cervical Cancer - Program helps to reach women in remote areas at risk for cervical cancer

Cervical Cancer Vaccine - DNA vaccines carrying HPV16 E7 peptide protect against cervical tumors

Chronic Myeloid Leukemia - Test available to monitor Gleevec resistance in people with CML

Chronic Myeloid Leukemia - Test launched to monitor Gleevec resistance

Clinical Trials - Clinical trial accrual among new cancer patients at cancer center discussed

Clinical Trials - Health Canada issues "No Objection" letter for cancer phase I clinical trial

Clinical Trials - U.S. FDA accepts first part of phase 3 trials with MCC-DNA complex for bladder cancer

Collaborations - Alliance forged with U.S. National Cancer Institute to develop RNAi therapeutics

Collaborations - Pharmaceutical biomarker research collaboration with Sanofi-aventis extended

Colon Cancer - Cell cycle arrest and apoptosis may be equipotent mechanisms in colon cancer

Colon Cancer - Doctors fail to recommend colon cancer tests for low-income patients

Colon Cancer - Effect of indomethacin on E-cadherin and beta-catenin expression in colon cancer studied

Colon Cancer - FOLFOX4 regimen is safe, effective for elderly colon cancer patients

Colon Cancer - Induction of oxidative metabolism by mitochondrial frataxin may inhibit cancer growth

Colon Cancer - Lessons from developing and running clinical database for colorectal cancer discussed

Colon Cancer - New findings in the area of colon cancer described

Colon Cancer - Oral uracil/ftorafur plus leucovorin treated metastatic colorectal cancer

Colon Cancer - Recent findings in colon cancer described

Colorectal Cancer - Lifestyle characteristics among patients in Norwegian colorectal cancer screening trial analyzed

Colorectal Cancer - Long-term outcomes of laparoscopic surgery for colorectal cancer reviewed

Colorectal Cancer - Mutations spread in the normal colon by crypt fission

Colorectal Cancer - PRL and survival of CRC patients affected by tumor location and radiotherapy

Colorectal Cancer - Patients operated for colorectal cancer linked to high risk of recurrence

Complementary & Alternative Medicine - Curcumin uses transcription factor Egr-1 to suppress epidermal growth factor receptor expression

Complementary & Alternative Medicine - Hydroxyanthraquinone compounds exhibited cancer inhibitory activity

Complementary & Alternative Medicine - Tuber lectin extract showed anti-cancer effect on human cancer cell lines

Cytomegalovirus Pathogenesis - CMV-encoded G-protein-coupled receptors actively modulate cellular signaling networks

DNA Research - Fragmented nucleosomal DNA unrelated to caspase-3 mRNA in lymphoma and myeloma

Dermatology - Skin tumors express stromal cell markers associated with cancer progression

Diabetes Research - LoxP-flanked glucosylceramide synthase allele influences glycosphingolipid synthesis

Diagnostics - Immunohistochemical markers used to identify mesothelioma from serous carcinoma

Diagnostics - New findings in diagnostics described

Diagnostics - New research in the area of diagnostics detailed

Diagnostics - Sentinel lymph node detection is enhanced by scintigraphy performed 1 hour postinjection

Diagnostics - Serum PSA levels discriminates between benign and malign prostatic pathologies

Diagnostics - Studies describe new findings in diagnostics research

Diagnostics - Vascular endothelial growth factor messenger RNA may predict liver metastases

Diet & Nutrition - Calcium plus vitamin D may contribute to reduced polyp formation

Diet & Nutrition - Low-fat diet benefits for women less than expected, Stanford researcher says

Disease Associations - Aberrant perforin maturation underlies hemophagocytic lymphohistiocytosis clinical diversity

Disease Associations - Breast cancer risk elevated in first-degree relatives of Crohn disease patients

Disease Associations - Choice of age cut-off for dyspepsia may decrease endoscopy workload

Disease Associations - Incidence of detecting pulmonary embolisms with CT in oncology patients analyzed

Disease Associations - Intraductal papillary mucinous neoplasms linked to extrapancreatic neoplasms

Disease Associations - Paget disease of bone diagnosed in patient with known prostate cancer

Disease Prevention - Study gives specifics on how eating vegetables may protect against cancer

Drug Delivery - Paclimer-based intracranial paclitaxel delivery safe in canine study

Drug Development - Dasatinib may affect neoplasms associated with gain-of-function KIT mutations

Drug Development - Dual tyrosine kinase inhibitor GW572016 hampers colon cancer cells

Drug Development - Guidance revised on Onconase phase IIIb trial for mesothelioma

Drug Development - New findings in drug development described

Drug Development - Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold developed

Drug Development - Phase Ib trial initiated for oral AP23573 in combination with doxorubicin chemotherapy

Drug Development - Sphingosine-1-phosphate receptor antagonism blocks unwanted angiogenesis

Drug Development - The cyclolignan picropodophyllin may treat multiple myeloma

Drug Development - Third clinical trial initiated for AEG35156 for oncology

Drug Development - U.S FDA grants approval for Carboplatin Injection, 600 mg

Drug Resistance - Recent findings in drug resistance described

Drug Resistance - Role of gamma-glutamyltransferase expression in cancer cells and drug resistance explored

Drug Safety - Imatinib mesylate effective in CML in late chronic and advanced phase and after SCT relapse

Dysembryoplastic Neuroepithelial Tumor - Long-term seizure outcome after surgery for dysembryoplastic neuroepithelial tumor can be predicted

End-of-Life Issues - Concordance of preferences between cancer patient and family for end-of-life care estimated

End-of-Life Issues - Factors predicting home death for terminally ill cancer patients identified

Environmental Health - Five million Istanbul residents could get cancer from daily intake of tap water

Environmental Health - Report shows half a million more asbestos claims are expected over the next several decades

Enzymology - Tyrosine kinase inhibitors modify tumor vessel response to radiotherapy

Ependymomas - Prognostic histopathologic features of ependymomas identified

Epstein-Barr Virus - Recent findings illuminate research in Epstein-Barr virus

Facilities - New Jersey hospital opens new $17 million Monter Cancer Center

Finance - Biopharma company reports revenues of $27.3 million

Finance - Biotech company reports 2005 financial results