Enzymology
Tyrosine kinase inhibitors modify tumor vessel response to radiotherapy
Published in Cancer Weekly, March 7th, 2006
"The response of the tumor microvasculature to ionizing radiation can be modified to improve tumor control in preclinical mouse models of cancer. Recent studies have shown that a variety of cancer drugs can improve the response of cancers to radiotherapy," investigators in the United States report.
"Protein TKIs have been shown to enhance radiation-induced destruction of blood vessels. Among these compounds are inhibitors of a broad spectrum-of receptor tyrosine kinases (RTKs). Inhibition of RTKs attenuates downstream signaling from various angiogenic growth factors,...
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Source: Cancer Weekly (2006-03-07)
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