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Lung Cancer

Aflatoxin B-1 altered expression of p53 in cytochrome P450-expressing lung cells

Published in Cancer Weekly, March 7th, 2006

Aflatoxin B-1 [AFB1 ] altered expression of p53 in cytochrome P450 (CYP)-expressing human lung cells.

"AFB1 is a potent dietary hepatocarcinogen in animals and probably in humans. Mutations (and altered expression) of the tumor suppresser gene p53 have been observed in liver tumors from patients exposed to high dietary AFB1 ," scientists writing in the journal Toxicological Sciences reported.

"Inhalation of AFB1 -laden grain dusts has been associated with an increased incidence of lung cancer in humans as well. We examined the effects of low concentrations of AFB1 on the expression of...

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