Lymphoma
Ablation of oncogenic ALK used to treat anaplastic large-cell lymphomas
Published in Cancer Weekly, March 7th, 2006
"ALCLs carry chromosome translocations in which the ALK gene is fused to several partners, most frequently, the NPM1 gene. We have demonstrated that the constitutive activation of ALK fusion proteins results in cellular transformation and lymphoid neoplasia," researchers in the United States reported.
"Herein, we specifically downregulated ALK protein expression by using small hairpin RNA (shRNA) targeting a sequence coding for the catalytic domain of ALK. The ablation of ALK leads to the down-modulation of known ALK downstream...
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Source: Cancer Weekly (2006-03-07)
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