Myeloid Tumors

Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors

Published in Cancer Weekly, March 7th, 2006

Recent research from the United States has reported that Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR. Myeloid leukemias in AKXD23 mice contain proviral insertions at Evi1, resulting in transcriptional activation.

"Although Evi1 is clearly involved in leukemia, gene transfer studies in mice with Evi1 fail to cause leukemia, arguing that cooperating events are necessary," wrote K.E. Boyd and colleagues, Yale University.

"We reanalyzed AKXD-23 tumors for cooperating proviral insertion and found that each tumor had a proviral insertion in Sox4, which encodes an HMG-box transcription factor. RNA analysis...

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Source: Cancer Weekly (2006-03-07)

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