Stem Cell Transplantation

Donor KIR genotype has major influence on CMV reactivation rate after T-cell replete SCT

Published in Cancer Weekly, March 7th, 2006

Donor KIR genotype has a major influence on the cytomegalovirus reactivation rate after T-cell replete stem cell transplantation.

According to recent research published in the journal Blood, "Reactivation of cytomegalovirus (CMV) is a common complication following allogeneic stem cell transplantation. Genetic determinants in the host and donor that may influence the rate of reactivation are currently unknown.

"Viral replication is controlled by T cells and natural killer (NK) cells and these share expression of killer immunoglobulin-like receptors (KIRs). We analyzed whether activatory KIRs carried by the donor influenced the subsequent rate...

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Source: Cancer Weekly (2006-03-07)

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