Apoptosis
Ceramide mediates caspase-independent apoptosis
Published in Cancer Weekly, March 14th, 2006
"Although numerous studies have implicated the sphingolipid ceramide in the induction of cell death, a causative function of ceramide in caspase-dependent apoptosis remains a highly debated issue. Here, we show that ceramide is a key mediator of a distinct route to programmed cell death (PCD), i.e., caspase-independent PCD," wrote L. Thon and colleagues, Universitatsklinikum Schleswig-Holstein Campus Kiel.
"Under conditions where apoptosis is either not initiated or actively inhibited, TNF induces caspase-independent PCD in L929 fibrosarcoma cells, NIH3T3...
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Source: Cancer Weekly (2006-03-14)
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