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Pancreatic Cancer

p8 proposed as new target of gemcitabine in pancreatic cancer cells

Published in Cancer Weekly, March 14th, 2006

p8 was proposed as a new target of gemcitabine in pancreatic cancer cells.

According to a study from France, "Gemcitabine is the only available chemotherapeutic treatment of pancreatic cancers. It is, however, moderately effective, showing a tumor response rate of only 12%."

"The aim of this work was to identify new pathways involved in the resistance of pancreatic cancer cells to gemcitabine, in the hope of developing new adjuvant strategies to enhance its therapeutic efficacy. Comparison of gene expression patterns of five human pancreatic cancer cell lines showing different degrees of resistance to gemcitabine revealed specific overexpression of...

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