Antiretroviral Therapy
Ritonavir has potent anti-NF-kappa B and antitumor effects
Published in Cancer Weekly, March 14th, 2006
"Adult T-cell leukemia (ATL), an aggressive malignancy of CD4+ T cells associated with human T-cell leukemia virus type I (HTLV-I) infection, carries a very poor prognosis because of the resistance of leukemic cells to any conventional regimen, including chemotherapy.
"We examined the effect of ritonavir, an HIV protease inhibitor, on HTLV-I-infected T-cell lines and primary ATL cells and found that it induced apoptosis and inhibited transcriptional activation of NF-kappa B in these cells," scientists writing in the journal Blood report.
"Furthermore," wrote M.Z....
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Source: Cancer Weekly (2006-03-14)
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