Drug Development

Dendrons with spermine surface groups are building blocks for nonviral vectors

Published in Cancer Weekly, March 21st, 2006

Dendrons with spermine surface groups are potential building blocks for nonviral vectors in gene therapy.

"This paper investigates a series of dendrons based on the Newkome dendritic scaffold that displays a naturally occurring polyamine (spermine) on their surface. These dendrons have previously been shown to interact with DNA in a generation dependent manner with the more highly branched dendrons exhibiting a strong multivalency effect for the spermine surface groups. In this paper, we investigate the ability of these dendrons to transfect DNA into cells (human breast carcinoma cells, MDA-MB-231, and murine myoblast cells, C2C12) as determined by the luciferase...

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Source: Cancer Weekly (2006-03-21)

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