Skin Cancer

Cutaneous melanoma metastasis to the lymph nodes is not predicted by neovascular biomarkers

Published in Cancer Weekly, March 21st, 2006

Cutaneous melanoma metastasis to the lymph nodes is not predicted by neovascular biomarkers.

According to recent research from Germany, "Malignant melanoma of the skin preferentially metastasizes via the lymphatic system. Novel molecular biomarkers, which are involved in malignant transformation, proliferation, angiogenesis and lymphangiogenesis, are currently under investigation to elucidate the risk for lymph node metastasis."

"To this end, the vascular endothelial growth factors VEGF-C and VEGF-D have been identified to promote lymphangiogenesis and lymphatic spread through activation of its receptor, vascular endothelial growth factor receptor-3...

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Source: Cancer Weekly (2006-03-21)

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