Melanoma
Platelet-activating factor acts as promoter of melanoma metastasis
Published in Cancer Weekly, March 28th, 2006
"Overexpression of cAMP-response element (CRE)-binding protein (CREB) and activating transcription factor (ATF) 1 contributes to melanoma progression and metastasis at least in part by promoting tumor cell survival and stimulating matrix metalloproteinase (MMP)-2 expression. However, little is known about the regulation of CREB and ATF-1 activities and their phosphorylation within the tumor microenvironment," scientists in the United States reported.
"We analyzed the effect of PAF, a potent phospholipid mediator of inflammation, for its ability to activate CREB and ATF-1 in 8...
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Source: Cancer Weekly (2006-03-28)
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