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Carcinogenesis

Hydrogen sulfide implicated as a genotoxic agent

Published in Cancer Weekly, April 4th, 2006

Hydrogen sulfide (H2 S) was implicated as a genotoxic agent.

According to a study from the United States, "H2 S produced by commensal sulfate-reducing bacteria, which are often members of normal colonic microbiota, represents an environmental insult to the intestinal epithelium potentially contributing to chronic intestinal disorders that are dependent on gene-environment interactions. For example, epidemiologic studies reveal either persistent sulfate-reducing bacteria colonization or H2 S in the gut or feces of patients suffering from ulcerative colitis and colorectal cancer. However, a mechanistic model that explains the connection...

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