Lymphoma
HA14-1 induced apoptosis in follicular lymphoma B cells
Published in Cancer Weekly, April 4th, 2006
"The BCL-2 overexpression is a hallmark of FL. Since patients with FL often suffer from resistant to chemotherapy refractory disease, the development of new regimens is required," researchers in Finland reported.
"Herein, we analyze for the first time the effects of a B-cell lymphoma 2 (Bcl-2) antagonist, HA14-1, alone and in combination with antineoplastic agents commonly used against FL, in human FL cell lines with t(14;18). All cell lines tested were sensitive to HA14-1-induced cytotoxicity and apoptosis, as depicted by morphological changes, SYTO16/PI staining,...
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Source: Cancer Weekly (2006-04-04)
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