Prostate Cancer

Prostate cancer apoptosis and growth inhibition induced by targeting c-myc gene

Published in Cancer Weekly, April 4th, 2006

According to research from Switzerland, growth inhibition and apoptosis is induced by daunomycin-conjugated triplex-forming oligonucleotides (TFOs) targeting the c-myc gene in prostate cancer cells.

"Covalent attachment of intercalating agents to TFOs is a promising strategy to enhance triplex stability and biological activity. We have explored the possibility to use the anticancer drug daunomycin as triplex stabilizing agent.

"Daunomycin-conjugated TFOs (dauno-TFOs) bind with high affinity and maintain the sequence-specificity required for targeting individual genes in the human genome. Here, we examined the effects of two dauno-TFOs targeting the...

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Source: Cancer Weekly (2006-04-04)

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