Hepatocellular Carcinoma

HCC is influenced by alcohol consumption and ADH2 and ALDH2 gene polymorphisms

Published in Cancer Weekly, April 10th, 2006

According to a study from Japan, hepatocellular carcinoma (HCC) is influenced by alcohol consumption and gene polymorphisms of alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) in a Japanese population.

"Although alcohol intake as well as hepatitis viruses has been associated with HCC, gene-alcohol interactions on HCC risk remain to be elucidated. We conducted a case-control study to examine whether polymorphisms of ADH2 and ALDH2 modified the HCC risk depending on the amount of alcohol intake," wrote T. Sakamoto and colleagues, Saga University.

"ADH2 and ALDH2 genotyping was performed by a duplex polymerase chain reaction with...

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Source: Cancer Weekly (2006-04-10)

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