Published in Cancer Weekly, April 10th, 2006
"A library of 2'-methoxyethyl-modified antisense oligonucleotides (2'MOE ASO) targeting 1,510 different genes has been developed, validated, and used to identify cell cycle regulatory genes.
"The most effective molecular target identified was Eg5 (kinesin-like-1), which when inhibited gave the largest increase in 4N DNA in various tumor cells," wrote E. Koller and colleagues, ISIS Pharmaceutical. "The Eg5 ASO reduced Eg5 levels,...
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