Published in Cancer Weekly, April 17th, 2006
Study 1: Antitumor immunity was induced by CTL epitopes genetically linked to membrane-anchored beta2 -microglobulin.
According to a study from Israel, "Level and persistence of antigenic peptides presented by antigen-presenting cells (APCs) on MHC class I (MHC-I) molecules influence the magnitude and quality of the ensuing CTL response. We recently demonstrated the unique immunological properties conferred on APCs by expressing beta2 -microglobulin (beta2 m) as an integral membrane protein. In this study, we explored...
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