Cancer Therapy
DNA methyltransferase inhibitors are angiostatic in tumors
Published in Cancer Weekly, April 24th, 2006
"Inhibitors of DNMTs and histone deacetylases can reactivate epigenetically silenced tumor suppressor genes and thereby decrease tumor cell growth. Little, however, is known on the effects of these compounds in endothelial cell biology and tumor angiogenesis," scientists in the Netherlands report.
"Here, we show that the DNMT inhibitors 5-aza-2'-deoxycytidine and zebularine markedly decrease vessel formation in different tumor models. We show that DNMT inhibitors are antiproliferative for tumor-conditioned endothelial cells, without affecting endothelial cell apoptosis and migration,"...
Want to see the full article?
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Cancer Weekly
Source: Cancer Weekly (2006-04-24)
More Articles from Cancer Weekly
- Astrocytomas
Gliomas graded using metabolite quantification with MR spectroscopic imaging - Colorectal Cancer
Colorectal cancer prognosis linked to indoleamine 2,3-dioxygenase expression - Lung Cancer
Lung cancer apoptosis enhanced by adenylate cyclase toxin - Ovarian Cancer
Ovarian cancer risk not linked to dietary fat, cholesterol and egg intakes - Prostate Cancer
Prostate cancer quality of life affected by spirituality - Abdominal Cancer
Habitual inclusion of pelvis on abdominal CT for abdominal tumors not justified - More from this issue of Cancer Weekly
NewsRx is Social
Follow us on your favorite social network by clicking on a button below:
Top Medical Newsletters
Awards
Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005
Facts & Stats
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.
- Google 2010 PageRank: #2 Among Top Health News and Media Publications
- Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
- Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
- Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry
