Published in Cancer Weekly, April 24th, 2006
Study 1: Scientists from the United States studied the functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum (ER) kinase and its relation to drug resistance of dormant carcinoma cells.
"It has been proposed that occult, disseminated metastatic cells are refractory to chemotherapy due to lack of proliferation. We have shown that p38 activation induces dormancy of squamous carcinoma cells," wrote A.C. Ranganathan and colleagues, State University of New York. "We now show that p38 signaling in...
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