Published in Cancer Weekly, April 24th, 2006
Study 1: Investigators have identified new NY-ESO-1 epitopes recognized by CD4+ T cells and presented by HLA-DQ B1 03011.
"NY-ESO-1 is one of the most immunogenic cancer antigens eliciting strong humoral and cellular immune responses in patients with NY-ESO-1-expressing malignancies. Since CD4+ T cells play a critical role in generating and maintaining antigen-specific cellular and humoral immune responses, we searched for new NY-ESO-1 epitopes presented by MHC class II molecules. CD4+ T cells of patients with NY-ESO-1-expressing cancer were presensitized with...
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