Published in Cancer Weekly, April 24th, 2006
"Mutations within the FLT3 gene are of growing importance for classification, risk assessment, and therapeutic targeting of acute myeloid leukemia (AML). We analyzed 656 AML patients for a recently described single-nucleotide polymorphism in the third immunoglobulin-like domain of the extracellular region of FLT3," wrote S. Schnittger and colleagues, University Hospital Grosshadern.
"The FLT3 D324N variant was present in 42 cases (6.4%), but it was not associated with a specific AML subtype and did not show an elevated...
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