Leukemia Vaccine

Rapid bone marrow transduction allows repopulation with hematopoietic stem cells

Published in Cancer Weekly, April 24th, 2006

Rapid one-hour transduction of whole bone marrow leads to long-term repopulation of murine recipients with lentivirus-modified hematopoietic stem cells.

According to a study from the United States, "Efficient gene transfer to hematopoietic stem cells by Moloney murine leukemia virus-derived retroviral vectors benefits from ex vivo culture and cytokine support. Both also increase the risks of apoptosis and differentiation among cells targeted for transduction. In an effort to maximize the retention of stem cell properties in target cells, we developed a transduction protocol with a focus on minimizing graft manipulation, cytokine stimulation, and ex vivo exposure...

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Source: Cancer Weekly (2006-04-24)

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