Pleural Mesothelioma

New human malignant pleural mesothelioma models produce excess VEGF

Published in Cancer Weekly, April 24th, 2006

New human malignant pleural mesothelioma (MPM) models produce excess vascular endothelial growth factor (VEGF).

"MPM is closely related to exposure to asbestos, and a rapid increase in the number of MPM patients in Japan is estimated in the years 2010-2050. The purpose of the present study was to establish a clinically relevant animal model that shows human patient-like progression of MPM," investigators in Japan report.

"Here, we demonstrate that a human MPM cell line (EHMES-10) inoculated orthotopically (thoracic cavity) into severe combined immunodeficiency (SCID) mice produces highly vascularized thoracic tumors with pleural dissemination and...

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Source: Cancer Weekly (2006-04-24)

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