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Rectal Cancer

Distal rectal cancer treated by neoadjuvant combined-modality chemoradiation

Published in Cancer Weekly, April 24th, 2006

Rectal cancer could be treated by neoadjuvant combined-modality chemoradiation.

Scientists in the United States conducted a study "to evaluate the rate of pathologic complete response and toxicity of neoadjuvant chemoradiation for advanced T3/74 distal rectal cancers in a randomized phase II study."

"Patients with clinical T3/T4 distal rectal cancers were randomly assigned in a phase II study to receive combined neoadjuvant chemoradiotherapy followed by surgical resection. Patients were randomly assigned to receive continuous venous infusion (CVI) fluorouracil (FU) 225 mg/m2 per day, 7 days per week, plus pelvic hyperfractionated radiation...

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