Lung Cancer

Lung cancer apoptosis enhanced by adenylate cyclase toxin

Published in Cancer Weekly, April 24th, 2006

Lung cancer apoptosis was enhanced by adenylate cyclase (AC) toxin from Bordetella pertussis.

According to recent research published in the journal Oncology Research, "The present study examined the possibility to enhance lung cancer cell cytotoxicity and apoptosis of the anticancer drug cisplatin by exposure with AC toxin from B. pertussis. A malignant mesothelioma cell line (P31) and a small-cell lung cancer cell line (U 1690) were exposed to increasing concentrations of cisplatin and AC toxin, alone or in combination."

"Cytotoxicity was determined by a fluorescein-based assay and apoptosis by flow cytometry quantification of...

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Source: Cancer Weekly (2006-04-24)

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