Published in Cancer Weekly, April 24th, 2006
According to recent research published in the journal Applied Immunohistochemistry & Molecular Morphology, "HIFs-1 alpha and HIF-2 alpha are important proteins initiating tumor cell responses to hypoxia. Specifically, the transcription of genes related to erythropoiesis, glycolysis, and angiogenesis depends on the rate of HIF alpha binding to DNA at the hypoxia response elements of target genes."
"In this study, the authors evaluated the immunohistochemical expression of HIF-2 alpha in 62 infiltrating ductal carcinomas of the breast, not otherwise...
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