Drug Development
Tetramer-blocking assay identifies antigen-specific CTLs
Published in Cancer Weekly, May 1st, 2006
"Peptide-MHC tetramers have been engineered to allow accurate detection of antigen-specific cytotoxic T lymphocytes by flow cytometry. We propose a novel use for peptide-MHC tetramers in the specific and sensitive analysis of the cytotoxic function of antigen-specific CTL by blocking MHC-restricted antigen-specific cytotoxicity," scientists in Japan report.
"We found that pretreatment of ovalbumin (OVA)-specific CD8+ CTL (OT-1 CTL), derived from OT1 1T-cell receptor (TCR)-transgenic mice, with...
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Source: Cancer Weekly (2006-05-01)
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