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Ovarian Cancer

Ovarian cancer prognosis linked to polymorphism in matrix metalloproteinase-1

Published in Cancer Weekly, May 1st, 2006

Ovarian cancer prognosis could be linked to a polymorphism in the matrix metalloproteinase-1 gene promoter (MMP1).

According to recent research from Austria, "The enzyme matrix metalloproteinase-1 (MMP-1) is involved in ovarian carcinogenesis. A common guanine insertion-deletion promoter polymorphism within the gene encoding MMP-1 (MMP1) has been suggested to be a candidate gene for ovarian cancer."

"We investigated whether this common polymorphism can also serve as independent prognostic parameter in a large series of affected women. The MMPI promoter polymorphism was examined in 151 Caucasian patients with epithelial ovarian cancer using polymerase...

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