Published in Cancer Weekly, May 1st, 2006
According to a study from the United States, "Adaptation to hypoxic microenvironment is critical for tumor survival and metastatic spread. HIF-1 alpha plays a key role in this adaptation by stimulating the production of proangiogenic factors and inducing enzymes necessary for anaerobic metabolism."
"HDACIs produce a marked inhibition of HIF-1 alpha expression and are currently in clinical trials partly based on their potent antiangiogenic effects. Although it has been postulated that HDACIs affect HIF-1 alpha expression by...
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