Molecular Biology

Histone deacetylase inhibitors produce ubiquitin-independent hypoxia-inducible factor 1 degradation

Published in Cancer Weekly, May 1st, 2006

Histone deacetylase inhibitors (HDACIs) produce ubiquitin-independent hypoxia-inducible factor 1 alpha (HIF-1 alpha) degradation.

According to a study from the United States, "Adaptation to hypoxic microenvironment is critical for tumor survival and metastatic spread. HIF-1 alpha plays a key role in this adaptation by stimulating the production of proangiogenic factors and inducing enzymes necessary for anaerobic metabolism."

"HDACIs produce a marked inhibition of HIF-1 alpha expression and are currently in clinical trials partly based on their potent antiangiogenic effects. Although it has been postulated that HDACIs affect HIF-1 alpha expression by...

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Source: Cancer Weekly (2006-05-01)

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