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Prostate Cancer

Prostate cancer apoptosis induced by berberine

Published in Cancer Weekly, May 1st, 2006

Prostate cancer apoptosis could be induced by berberine.

"Berberine, a naturally occurring isoquinoline alkaloid, has been shown to possess anti-inflammatory and antitumor properties in some in vitro systems. Here, we report that in vitro treatment of androgen-insensitive (DU145 and PC-3) and androgen-sensitive (LNCaP) prostate cancer cells with berberine inhibited cell proliferation and induced cell death in a dose-dependent (10-100 mcmol/L) and time-dependent (24-72 hours) manner," scientists in the United States reported.

"Treatment of nonneoplastic human prostate epithelial cells (PWR-1E) with berberine under identical conditions did not...

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