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Prostate Cancer

Prostate cancer prevention with synthetic dimer of indole-3-carbinol promising

Published in Cancer Weekly, May 1st, 2006

A novel synthetic dimer of indole-3-carbinol shows promise for use in prostate cancer chemoprevention.

"Cruciferous vegetables have been found to have antiprostate cancer effects," scientists in the United States explained. "The active compounds mediating these effects include indoles such as indole-3-carbinol (I3C) and isothiocyanates."

"I3C is unstable having tissue tropic effects, and clinical utility has been partly addressed by the synthesis of a more stable dimer diindolylmethane (DIM)," noted V.P.S. Garikapaty and colleagues at New York Medical College. In their study, "antiproliferative activity was measured by XTT assay and cytosolic...

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