Breast Cancer

Breast cancer therapy using steroid sulfatase inhibitor STX 64 appears promising

Published in Cancer Weekly, May 1st, 2006

Breast cancer therapy using the steroid sulfatase inhibitor STX 64 appears promising.

According to scientists at Imperial College in London, "Inhibition of steroid sulfatase (STS), the enzyme responsible for the hydrolysis of steroid sulfates, represents a potential novel treatment for postmenopausal women with hormone-dependent breast cancer. Estrone and DHEA are formed by this sulfatase pathway and can be converted to steroids (estradiol and androstenediol, respectively), which have potent estrogenic properties."

"Experimental STX64 (667 Coumate), a tricylic coumarin-based sulfamate that irreversibly inhibits STS activity, was selected for entry...

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Source: Cancer Weekly (2006-05-01)

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