Cancer Gene Therapy

Stable gene silencing of cyclin B1 in tumor cells increases Taxol susceptibility

Published in Cancer Weekly, May 1st, 2006

According to a study from Germany, stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo.

"Cyclin B1 is the regulatory subunit of cyclin-dependent kinase 1 (Cdk1) and is critical for the initiation of mitosis. Accumulating data indicate that the deregulation of cyclin B1 is tightly linked to neoplastic transformation," wrote J. Yuan and colleagues, University of Frankfurt.

They continued, "To study the phenotype and the potential preclinical relevance, we generated HeLa cell lines stably transfected with the plasmids encompassing short hairpin RNA (shRNA) targeting cyclin B1."

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Source: Cancer Weekly (2006-05-01)

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