Published in Cancer Weekly, May 8th, 2006
According to a study from the United States, "Cox-1 and Cox-2 are two distinct isoforms that catalyze the conversion of arachidonic acid to prostaglandins. The role of Cox-2 in a variety of cancers is well recognized, but the contribution of Cox-1 remains much less explored."
"We have previously shown that human epithelial ovarian tumors have increased levels of Cox-1, but not Cox-2," explained T. Daikoku and colleagues, Vanderbilt University. "We also observed that Cox-1 is highly expressed in a mouse model of EOC, which lacks p53 but overexpresses c-myc and...
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