Tumor Suppression

Heparins vary widely in ability to interfere with P-selectin-mediated cell binding

Published in Cancer Weekly, May 15th, 2006

Heparins vary widely in their ability to interfere with P-selectin-mediated cell binding.

According to recent research published in the journal Thrombosis and Haemostasis, "Ample evidence suggests that many of the in vivo antimetastatic effects by heparins reflect their actions on P-selectin-mediated binding.

"We hypothesized that the ability of widely used heparins and derivatives to interfere with P-selectin-dependent tumor cell interactions under flow in vitro could be used to identify anticoagulants with advanced inhibitory functions on experimental blood-borne metastasis in vivo."

"To test this assumption," R.J. Ludwig...

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Source: Cancer Weekly (2006-05-15)

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