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Gastrointestinal Cancer

Gastrointestinal cancer peritoneal metastasis is inhibited by linoleic acid

Published in Cancer Weekly, May 29th, 2006

According to recent research from Japan, gastrointestinal cancer peritoneal metastasis is inhibited by linoleic acid (LA) with activation of peroxisome proliferator-activated receptor gamma (PPAR gamma).

"The effect on peritoneal metastasis of LA was examined using in vitro treatment of cancer cells and mouse peritoneal metastasis models," wrote T. Sasaki and colleagues, Nara Medical University.

"Firstly, cell growth of MKN28 human gastric cancer cells and Colo320 human colon cancer cells was suppressed by LA in a dose-dependent manner with increment of apoptosis. LA-induced growth inhibition was recovered by the exposure to antisense...

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