Immunotherapy

Immunotherapy targets latent membrane protein 1 in EBV-associated NK cell lymphoma

Published in Cancer Weekly, May 29th, 2006

Immunotherapy may be used to target latent membrane protein 1 in Epstein Barr-associated natural killer cell lymphomas.

"Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP) 1 is a potential target for immunotherapy of some proportion of Hodgkin's disease cases, nasopharyngeal carcinomas, EBV-associated natural killer (NK)/T lymphomas, and chronic active EBV infection (CAEBV).

"Since it is unknown whether EBV-infected NK/T cells are susceptible to lysis by LMPl-specific cytotoxic T lymphocytes (CTL), we here tested the ability of mRNA-transduced antigen-presenting cells (APC) to stimulate rare LMP1-specific CTL," scientists writing in the...

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Source: Cancer Weekly (2006-05-29)

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