Lung Cancer
Lung carcinogenesis linked to reduced HAUSP gene expression
Published in Cancer Weekly, May 29th, 2006
"HAUSP directly stabilizes the tumor suppressor p53 by de-ubiquitination. Therefore, the HAUSP gene might play an important role in carcinogenesis," scientists in Japan reported.
"In this paper, HAUSP expression and p53 gene status have been studied in relation to the expression of p53 target genes in 131 patients with non-small cell lung cancer (NSCLC). p53 gene status was evaluated by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) followed by sequencing. Quantitative reverse-transcription...
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Source: Cancer Weekly (2006-05-29)
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