Apoptosis

Cytotoxic T lymphocyte-induced killing differs from apoptosis and perforin-dependent lysis

Published in Cancer Weekly, June 5th, 2006

According to recently published research from Australia, cytotoxic T lymphocyte (CTL)-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.

"CTL-induced death triggered by the granule exocytosis pathway involves the perforin-dependent delivery of granzymes to the target cell. Gene targeting has shown that perforin is essential for this process; however, CTL deficient in the key granzymes A and B maintain the ability to kill their targets by granule exocytosis," wrote N.J. Waterhouse and colleagues, Peter MacCallum Cancer Center.

"It is not clear how granzyme AB(-/-) CTLs kill...

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Source: Cancer Weekly (2006-06-05)

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