Published in Cancer Weekly, June 5th, 2006
"CTL-induced death triggered by the granule exocytosis pathway involves the perforin-dependent delivery of granzymes to the target cell. Gene targeting has shown that perforin is essential for this process; however, CTL deficient in the key granzymes A and B maintain the ability to kill their targets by granule exocytosis," wrote N.J. Waterhouse and colleagues, Peter MacCallum Cancer Center.
"It is not clear how granzyme AB(-/-) CTLs kill...
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