Published in Cancer Weekly, June 5th, 2006
"The INhibitor of Growth (ING) family of plant homeodomain (PHD) proteins induce apoptosis and regulate gene expression through stress-inducible binding of phospholipids with subsequent nuclear and nucleolar localization. Relocalization occurs concomitantly with interaction with a subset of nuclear proteins, including PCNA, p53 and several regulators of acetylation such as the p300/CBP and PCAF histone acetyltransferases (HATS), as well as the histone deacetylases HDAC1 and hSir2," scientists writing in the journal Experimental Cell Research reported.
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