Lung Cancer

Lung carcinoma poor prognosis and tobacco smoking linked to hypermethylation of TSLC1/IGSF4 promoter

Published in Cancer Weekly, June 5th, 2006

Poor prognosis of nonsmall cell lung carcinoma (NSCLC) and tobacco smoking were linked to hypermethylation of the TSLC1/IGSF4 promoter.

According to recent research published in the journal Cancer, "The tumor suppressor gene TSLC1/IGSF4 on chromosomal region 11q23 is frequently inactivated by promoter methylation in various cancers, including NSCLC. Several studies have demonstrated that the hypermethylation of the CpG islands of genes, including tumor suppressors, is associated with exposure to tobacco smoke."

"The purpose of this study was to investigate the possible association of TSLC1/CSF4 methylation with tobacco smoking as well as with...

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Source: Cancer Weekly (2006-06-05)

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