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Breast Cancer

Breast cancer prognosticated by activated leukocyte cell adhesion molecule overexpression

Published in Cancer Weekly, June 5th, 2006

Breast cancer could be prognosticated by cytoplasmic overexpression of activated leucocyte cell adhesion molecule (ALCAM).

According to a study from Germany, "ALCAM (CD166) is a cell surface member of the immunoglobulin superfamily. ALCAM expression has prognostic relevance in prostate and colon cancer."

"To evaluate ALCAM protein expression in breast cancer by immunohistochemistry and to correlate expression levels with clinicopathological data, 162 primary breast carcinomas with a mean clinical follow up time of 53 months were immunostained using a monoclonal ALCAM antibody," explained M. Burkhardt and colleagues, Charite-Universitatsmedizin. "The...

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