Prostate Cancer Vaccine

Antibody can detect Kai1/CD82 murine metastasis suppressor

Published in Cancer Weekly, June 5th, 2006

Scientists characterize an antibody that can detect the Kai1/CD82 murine metastasis suppressor in a recent issue of the journal Prostate.

"Kai1, also known as CD82, is a member of the tetraspanin family (TM4SF). The human homolog, KAI1, is an activation antigen of T-cells and is a metastasis suppressor for prostate and other cancers. Little is known about the mouse protein because of the lack of antibody reagents," scientists in the United States noted.

"Peptide immunized rabbits were used to generate polyclonal antibody to Kai1," said Mary C. Custer and colleagues at the U.S. National Cancer Institute. The antibody was analyzed using...

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Source: Cancer Weekly (2006-06-05)

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