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Neuroendocrine Tumors

Delivered tumor dose for neuroendocrine tumors increased by combining I-131-MIBG with Y-90-DOTATOC

Published in Cancer Weekly, June 19th, 2006

Delivered tumor dose for radiotherapy of neuorendocrine tumors was increased by combining I-131-Metaiodobenzylguanidine (I-131-MIBG) with Y-90-DOTA-D-Phe1-Tyr3-octreotide (Y-90-DOTATOC).

"I-131-MIBG and Y-90-DOTATOC have been used as radiotherapeutic agents for treating neuroenclocrine tumors. The tumor dose delivered by these agents is often insufficient to control or cure the disease," researchers in the United States reported.

"However, these 2 agents used together could potentially increase tumor dose without exceeding the critical organ dose because the dose-limiting tissues are different," explained M.T. Madsen and colleagues, University of...

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