Published in Cancer Weekly, June 19th, 2006
Study 1: Lymphoma apoptosis was induced by down-regulating constitutive activation of the nuclear factor-kappa B (NF-kappa B) canonical pathway.
"Constitutive activation of the NF-kappa B pathway has been shown to be involved in the resistance of tumor cells to apoptosis in several human malignancies of the hematopoietic lineage. By using electrophoretic mobility shift assay (EMSA) and confocal microscopic analysis, we demonstrate that NF-kappa B is constitutively activated in cutaneous T-cell lymphoma (CTCL) cell lines HuT-78, MyLa, and SeAx and in peripheral...
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