Non-Hodgkin Lymphoma
Non-Hodgkin lymphoma susceptibility predicted by haplotypes in TNF region
Published in Cancer Weekly, June 19th, 2006
"The cytokines TNF alpha and lymphotoxin-alpha (LT alpha) are known to play key roles in B-cell growth, differentiation and maturation. Genetic polymorphism within regulatory regions of these cytokine genes can alter expression levels and may be important in development of lymphoid malignancy," researchers in England reported.
"This study investigates a number of single nucleotide polymorphisms (SNPs) and microsatellite variants present within these genes in a large cohort of NHL cases including 211 cases of...
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Source: Cancer Weekly (2006-06-19)
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