Published in Cancer Weekly, July 4th, 2006
Researchers in Italy investigated "whether polymorphisms with putative influence on fluorouracil/cisplatin activity are associated with clinical outcomes of patients with AGC. Peripheral blood samples from 175 prospectively enrolled AGC patients treated with fluorouracil/cisplatin palliative chemotherapy were used for genotyping 13 polymorphisms in 9 genes (TS, MTHFR, XPD, ERCC1, XRCC1, XRCC3, GSTPI, GSTTI, GSTMI). Genotypes were correlated to response and survival."
"The overall response rate was 41%,...
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