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Intracranial Ependymoma

Intracranial ependymoma and choroid plexus papilloma tumorigenesis linked to methylation pattern

Published in Cancer Weekly, July 4th, 2006

Mechanism of tumorigenesis of childhood intracranial ependymoma (EP) and benign choroid plexus papilloma (CPP) might be linked to methylation pattern of RASSFIA and TRAIL pathway-related genes.

According to a study from France, "EP represent the third most frequent type of central nervous system (CNS) tumor of childhood, after astrocytomas and medulloblastomas. No prognostic biological markers are available, and differentiation from CPP is difficult."

"The present objective was, for a sample of 27 children with intracranial EP and 7 with CPP, to describe and compare the methylation status of 19 genes (with current HUGO symbol, if any): p15INK4a...

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