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Cervical Cancer

High cervical cancer incidence in China linked to high frequency of HPV16 Asian variants

Published in Cancer Weekly, July 11th, 2006

The high incidence of cervical cancer in China could be linked to a high frequency of human papillomavirus type 16 (HPV16) Asian variants.

"HPV16 has a number of intratypic variants; each has a different geographical distribution and some are associated with enhanced oncogenic potential. Cervical samples were collected from 223 cervical cancer patients and from 196 age-matched control subjects in China," investigators in the People's Republic of China reported.

"DNA samples were amplified by using primers specific for the E6, E7 and partial L1 regions," explained Y.P. Wu and colleagues, Sun Yat Sen University. "Products were sequenced and analysed....

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